Skip to main content

The link between NSAID medications and Peptic Ulcer

NSAID means Non-Steroidal Anti-Inflammatory Drugs. Common NSAID drugs include aspirin,  ibuprofen, diclofenac, etc. Most of us are aware of aspirin, which is actually a blood thinner used as medication for heart diseases. We are also aware of ibuprofen which is a known pain killer. It may sound surprising that prolonged use of NSAID drugs can cause peptic ulcer. What mechanism makes them cause peptic ulcer?

How do NSAID drugs work?

Generally the stomach and duodenum lining are under constant attack from the digestive juices which are very potent. The body has a mechanism to protect the cells or tissues that line the stomach and duodenum. This also explains why the cells found in the stomach lining get replaced so quickly (every four days). Some enzymes like COX-1 or COX-2 are required to convert the stomach acid to compound like prostaglandin which are non-detrimental to the stomach lining.
The NSAID drugs functions by inhibiting the COX-1 and COX-2 enzyme formation. This inhibition has a consequence in reducing the prostaglandin secretion of the stomach which is needed to protect the lining. This causes damage to the stomach lining in the long run.

Details of Combined Risk Factors along with NSAID Drug usage

People who have a past history of peptic ulcer, are above the age of 65, have heart conditions, and are some of the factors that can augment the formation of peptic ulcer along with prolonged use of NSAID drugs.

H.pylori and NSAID drugs – The combined risk factors for peptic ulcer

It has been found clinically that people who have a history of prolonged usage of NSAID drugs like aspirin, ibuprofen, diclofenac etc., and who are also infected with H.pylori, are 60% more likely to contract peptic ulcer. This shows that both are a double whammy and indeed can cause peptic ulcer in majority of cases.
So for patients who are regularly under NSAID drugs some relief can be provided by screening the H.pylori in their system. The risk of ulcer can be reduced significantly if the H.pylori is screened and eradicated in their digestive track before going in for NSAID prescription for other ailments which necessitates NSAID prescription.

Can NSAID drugs be avoided altogether?

The answer is no. Many NSAID drugs are actually life savers. Aspirin for example is a wonder drug that is used for treating a wide variety of ailments. Particularly for people suffering from arthritis and other inflammatory conditions, some NSAID drugs are absolutely needed. The challenge is to minimize the effect of NSAID drugs to cause stomach ulcerations. Though there are alternative medicines, they have limitations. The medical professional hence balances out and prescribes a lower dosage of NSAID and keeps the gastro track under constant monitoring for any damage that might arise due to peptic ulcers.
http://www.springfieldwellnesscentre.com/link-between-nsaid-drugs-peptic-ulcer/
Labels:

Comments

Post a Comment

Popular posts from this blog

முகக்கவசம் கொரோனா வைரசிலிருந்து நம்மை காப்பாற்றுமா?

முகக்கவசம் என்று சொல்லக்கூடிய Face Mask கொரோனா வைரசிலிருந்து நம்மை காப்பாற்றுமா? WHO என்று சொல்லப்படும் உலக சுகாதார நிறுவனம் செய்யும் பரிந்துரைகள் என்ன? https://www.youtube.com/watch?v=pI_3-hajIAE Visit Springfield Wellness Centre to get treated by Dr Maran , the best bariatric surgeon in Chennai , who has done many bariatric surgery in Chennai and many metabolic surgery in Chennai. For More Information about weight loss surgery in Chennai , visit us at https://springfieldwellnesscentre.com/ Mail us at springfieldinfo@gmail.com Call us at (91) 9952002927to book an appointment
Post a Comment
Read more

Complications of Abdominal Wall Hernia

Hernia correction surgery is one of the common surgeries performed these days. They happen by thousands every year throughout India. Despite this many do not perform Hernia surgery due to reasons like fearing a surgery, postponing the surgery for many reasons like financial shortage, poor diagnosis (happens mostly in rare hernia cases), etc. However it may be noted that not getting your Hernia treated surgically can lead to other complications which are sometimes life threatening too. http://www.springfieldwellnesscentre.com/complications-abdominal-wall-hernia/
Post a Comment
Read more

Abscess in Appendix

One of the complications of a burst  #appendix  is the formation of something called  #abscess  around the area where the burst has happened. An abscess is a collection of pus around the area. This collection of pus is because the body's immune system has been fighting the infection. The treatment for abscess is usually administering antibiotics. But before administering the antibiotics, when appendectomy is done, the pus in the abscess area is drained mandatory as part of the cleaning of the abdomen.
Post a Comment
Read more